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Effects of naloxone: A post-overdose care plan

Being revived through naloxone, while lifesaving, is usually a very unpleasant experience for both the overdosed individuals and the individual who administers naloxone. This resource spells out common side effects of naloxone use on opioid-dependent people and provides a list of suggested items useful for post-overdose care.

NACo Opioid Solutions Strategy Brief: Naloxone to Reverse Opioid Overdose

This strategy brief shares basic evidence of naloxone effectiveness and also highlights innovative methods for distribution.

RTI – Optimizing naloxone distribution to prevent opioid overdose fatalities

The objective of this study was to pilot test a multi-component implementation strategy-the systems analysis and improvement approach for naloxone (SAIA-Naloxone) which included (1) analyzing program data to identify gaps in the naloxone delivery cascade, (2) flow mapping to identify causes of attrition and brainstorm programmatic changes for improvement, and (3) conducting continuous quality improvement to test and assess whether modifications improve the cascade.

Compassionate Overdose Response: Summit Highlights and Key Takeaways

Forty experts participated in consensus-building discussion on a standard of care opioid overdose response protocol. A critical message emerged: those responding to an overdose should aim to restore breathing without causing withdrawal by supporting the person’s breathing, giving low or standard doses of naloxone (0.4 mg intramuscular injection and <4 mg intranasal spray) until spontaneous breathing is restored, and creating a calm environment. Despite fluctuations in the drug supply, standard dose naloxone is effective.

Training Guide: Guide to Developing and Managing Overdose Prevention and Take Home Naloxone Projects, NHRC

Providing overdose prevention, recognition, and response education to people who use drugs, their neighbors, friends, families, and the service providers who work with them is a harm reduction intervention that saves lives. This training guide outlines the process of developing and managing an Overdose Prevention and Education Program.

Estimating naloxone need in the USA across fentanyl, heroin, and prescription opioid epidemics: a modelling study

The US overdose crisis is driven by fentanyl, heroin, and prescription opioids. One evidence-based policy response has been to broaden naloxone distribution, but how much naloxone a community would need to reduce the incidence of fatal overdose is unclear. We aimed to estimate state-level US naloxone need in 2017 across three main naloxone access points (community-based programmes, provider prescription, and pharmacy-initiated distribution) and by dominant opioid epidemic type (fentanyl, heroin, and prescription opioid).

Best practices for community-based overdose education and naloxone distribution programs: results from using the Delphi approach

We utilized a modified Delphi approach to develop a set of best practices for OEND delivery. The top 5 ranked best practices were ensuring that SSP participants have low barrier, consistent, needs-based access to naloxone and that there is ample naloxone available within communities. While the remaining fifteen best practices were deemed important, they had more to do with organizational culture and implementation climate.

Vital Strategies – Overdose Prevention Centers Fact Sheet

Overdose prevention centers are public health facilities that provide people with a non-judgmental, hygienic, supervised space to use their drugs. Centers are staffed by peers and usually also healthcare professionals who are trained to intervene immediately in the event of an adverse drug event, such as an overdose. People who visit the centers to use drugs receive safer use supplies free of charge, such as sterile syringes, tourniquets, cookers, and cotton.

A Look Inside Life-Saving Overdose Prevention Centers – Video 

In 2021, OnPoint NYC opened the first sanctioned overdose prevention centers, or OPCs, in the U.S. They reversed 600 overdoses in their first year of operation and connected thousands of people with addiction services and social supports, including voluntary treatment. We spoke with OnPoint’s staff to learn how OPCs are saving lives.

XA Look Inside Life-Saving Overdose Prevention Centers – Video
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